These two related work packages (WP4 and WP5) will create modular and generic G2P database components, and then use these building blocks to construct major demonstration databases for use by the field. All of this work will be based upon the standards developed in WP3. The main distinction between these two work packages is that WP4 will concentrate upon genetics databases (i.e., where the focus is on one or a few genes or diseases, with clinical utility being most important) whereas WP5 will concentrate upon summary level genomics databases (i.e., aggregated datasets, where there is no focus on any particular gene or disease, and with research utility being most important). The two workpackages will implement rather different user interfaces, with WP4 oriented mostly towards the needs of clinical users and WP5 oriented more towards biomedical researchers. WP4 and WP5 are therefore complementary, and will benefit from close co-operation as their respective tools and software solutions are developed. Furthermore, in both cases, the database components and/or complete databases produced will be used as tangible assets around which federated teams of (existing and new) database operators can grow, and this will be actively encouraged by activities in these work packages. WP4 and WP5 involve substantial technology development, and, as such, will be subject to quality assurance measures dictated by WP1. Both work packages will generate operational databases, and these will be used for the data gathering efforts performed in WP7. These databases will also be valuable in their own right, and in that capacity they represent example depositories that will be integrated and made universally searchable by the activities of WP6.