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Gene–environment-wide association studies: emerging approaches

Contributed by:Administrator
Originally posted:9th March 2010: 10:16 am
Last updated:18th March 2010: 11:30 am
Short URL:http://gen2phen.org/node/14103
Public document Public - anyone can view
DOI: 
10.1038/nrg2764
URL: 
http://feeds.nature.com/~r/nrg/rss/aop/~3/bW4rInYNcHU/nrg2764

Despite the yield of genome-wide association studies, the variants identified explain little of the heritability of most complex diseases. This unexplained heritability could be partly due to gene–environment (G×E) interactions. This Review provides a guide to designs and analytical approaches for studying specific G×E interactions.

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