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Genotype imputation for genome-wide association studies

Contributed by:Administrator
Originally posted:3rd June 2010: 9:52 am
Last updated:18th June 2010: 11:30 am
Short URL:http://gen2phen.org/node/22666
Public document Public - anyone can view
DOI: 
10.1038/nrg2796
URL: 
http://feeds.nature.com/~r/nrg/rss/aop/~3/lC279-XR6wY/nrg2796

Genotype imputation is an important tool for genome-wide association studies as it increases power, aids in fine-mapping of associations and facilitates meta-analyses. This Review provides a guide to and comparison of imputation methods and discusses association testing using imputed data.

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